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The ADMET (absorption, distribution, metabolism, excretion, and toxicity) prediction study showed that compound 12 exhibited adequate physicochemical, pharmacokinetic, and safety properties when compared to allopurinol and febuxostat

In immunocompromised patients, prior fungal colonization in the lower respiratory airways is considered an important risk factor for the development of invasive aspergillosis (10)

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Often we choose V max values so that the steady state concentrations of substrates and products lie within the normal published ranges