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Endocr Relat Cancer (2013) 20:495505

In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper (see DOSAGE AND ADMINISTRATION, and WARNINGS)

The Lancet Regional HealthWestern Pacific , 33 Martins, A., Barros, L., Carvalho, A

Park EO, Bae EJ, Park BH, Chae SW

Because AOD9604 does not stimulate IGF-1 production and lacks strong GH receptor agonism, it may present a safer alternative for long-term OA treatment [1]

pmid:22580721 3
