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Studies demonstrate that copper triggers abnormal aggregation by directly binding lipoylated proteins, leading to protein toxicity stress and cell death (183)

History of zinc as related to brain function

Cognitive dysfunction in these individuals is characterized by confusion, sleep disturbances, and, in severe cases, deep coma ( Hemodialytic therapy is considered a major contributor to chronic dialysis encephalopathy (57), particularly in hemodialysis

Certain studies suggest that vitamin C may also convert oxidized glutathione back to a useful form

RI: risk index

379 Monofunctional adducts could also conceivably form, 380,381 but the generally slow kinetics of ligand substitution at platinum(IV) argue against this process being of great biological relevance