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REDEFINE 1 and REDEFINE 2 ran 68 weeks, with the first ~16 weeks dedicated to dose titration

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Researchers comparing monoagonist vs dual agonist pharmacology, or studying adipose tissue GIP receptor expression, will find tirzepatide a useful comparator to semaglutide (GLP-1 only) and retatrutide (GIP + GLP-1 + glucagon)

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Bromberg A, Lerer E, Udawela M, Scarr E, Dean B, Belmaker RH, Ebstein R, Agam G (2012) Nicotinamide- N -methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels

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