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EV3A, lanes 4, 6, 10, 12)

Stages of embryonic development of the zebrafish

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In liver regeneration (LR) studies, after partial hepatectomy (PHx), HSCs exhibited high glycolytic metabolic flux and increased PFKFB3 expression in the liver and cells, and LR after PHx involved the activation of PFKFB3 in HSCs, as well as an increase in PFKFB3 to promote the production of the glycolysis product lactic acid, which promotes the proliferation of HSCs through the p38/ERK MAPK signaling pathway (76)

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Int Immunopharmacol 92:107353