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Furthermore, xCT deletion had no effect on age-related sarcopenia and dynapenia (Fig

Mechanical or inflammatory injury to the hypothalamus alters neuroendocrine secretion and contributes to systemic insulin resistance induced by inflammation/hyperglycemia, further impairing metabolic regulation and glucose uptake [60]

This study was also funded by the National Natural Science Foundation of China (32102724)

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During maturation, the NOTCH precursor undergoes a complex process of modifications and cleavages, like the S1 cleavage catalyzed by a furin-like protease before translocation of the mature protein to the cell membrane (Kopan and Ilagan, 2009)