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Mechanistically, they promote the translocation of Ahr into the nucleus, where it competes with hypoxia-inducible factor (HIF)-1 for binding to the Ahr nuclear translocator (ARNT), thus inhibiting HIF-1-mediated cardioprotective effects like NO and vascular endothelial growth factor (VEGF) production (Li W

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PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis

While PI3K/Akt is involved in IGF-1 signaling of hair follicle growth via IRS-1, epidermal growth factor (EGF) can activate the same pathway via Src

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