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This article summarizes what the preclinical work reports, what a regulator would note about the absent human dataset, and the self-reported community adverse-event picture

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23 Supplementation of 1 mg daily is recommended for patients with specific risk factors (e.g., bariatric/gastric surgery patients, those with severe malnutrition, chronic alcohol use, chronic hemolytic anemia and conditions with high cell turnover, and use of antimetabolite medications such as methotrexate)

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