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The 12mg weekly arm produced a 24.2% mean body weight reduction over 48 weeks, with 26% of participants achieving at least 30% total body weight loss a threshold previously unattained by any pharmacological intervention in a clinical trial setting

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Gene set enrichment analysis (GSEA) was performed using the fgsea R package on the ontology gene sets retrieved from gsea-msigdb.org ( An FDR threshold of 0.1 was implemented