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Lower serum sex hormone-binding globulin (SHBG) levels have been reported in individuals with GSD Ia displaying an inverse association with intrahepatic lipid content, thus supporting a connection between metabolic (im)balance and circulating sex hormone levels [169]

Pharmacological therapy (e.g., lipid-lowering drugs, granulocyte colony-stimulating factor, ACE-inhibitors) can correct secondary metabolic disturbances and/or prevent/delay disease complications

Hansen, E.S

CNS Spectr

This trend reflects a broader shift toward comprehensive metabolic management that addresses multiple physiological pathways simultaneously

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