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Telford, R

With the pre-mixture with GSH, the absorbance of the TMB-pFeSAN system at 652 nm hardly increased with time due to the reductive ability of GSH (Supplementary Fig

The hydroxyl and hydroperoxyl radicals are the eponyms of a family of Reactive Oxygen Species (ROS), which disruptively react with biological structures, such as unsaturated lipids of cellular membranes, the backbone and bases of DNA and essential chemical groups of catalytic and signaling proteins

By modulating mitochondrial dynamics, antioxidant defences, protein-quality control, stress responses and multiple signalling cascades, it emerges as a compelling therapeutic target for diseases driven by redox imbalance, protein misfolding and inflammation (Fig

F.Perales-PatnJ.TheelenT

doi: 10.2147/JIR.S306849