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MAJOR FEATURES OF THE LESION (2 points each): Change in size Irregular shape Irregular colour MINOR FEATURES OF THE LESION (1 point each): Largest diameter 7mm or more Inflammation Oozing Change in sensation Patients should also be referred urgently (within 2 weeks) if dermoscopy suggests melanoma skin cancer and if a pigmented or non-pigmented skin lesion is suggestive of nodular melanoma or other forms of rarer skin cancers

doi:10.1016/j.pnpbp.2006.06.012

In addition to the liver-directed and immunotherapy-based approaches described above, there have been numerous studies evaluating targeted therapies