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19 Serum levels of TRX-1 were increased in patients with sepsis compared to healthy individuals, and it was noted that non-survivors showed even higher TRX-1 levels compared to survivors

That is the honest state of the evidence

these models require much higher cell numbers to build-up a tight monolayer and longer cultivation times to reach stable TEER values (Cucullo et al., 2002, 2011)

this also suggests a potential protective role of estrogens (Shimizu 2007)

This level of partial STAT3 agonism was nonetheless sufficient to promote satiety and weight loss in leptin-deficient obese (ob/ob) mice (Supplementary Fig