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Considering that the majority of available data come from animal studies with a daily dose of 20 mg/kg, using the calculation based on body surface area proposed by Nair and Jacob in 2016 [43], we can hypothesize that the human equivalent dose could be 1.6 mg/kg, or 112 mg per 70 kg for an adult

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The present study demonstrates that chronic administration of LC increases cholinergic synaptic transmission, thereby enhancing cognitive function in aging rats [208]

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Their natural history is modified by various influencing factors, e.g., infection, genetic and environmental reasons
