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FOS positive expression (FOS+) represented the neurons activated by specific stimuli

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Cymbopogon citratus alleviates mancozeb- mediated renal toxicity in a rat model through combating inflammation, oxidative stress, and apoptosis

These cytokines not only directly damage chondrocytes but also act back on the synovium and other chondrocytes, creating a self-amplifying vicious cycle of inflammation along the cartilage-synovium axis

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Therapeutic strategies ranging from supplementation to transporter-targeted approaches show preclinical promise and early clinical signals