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A clinical proof-of-concept trial used 0.03 mg/kg twice daily for short durations and found the drug to be generally well tolerated, though efficacy endpoints were mixed depending on the indication

In mouse oocytes, Epitalon significantly reduced levels of H2AX, a marker of DNA double-strand breaks, and prevented apoptosis [46]

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These processes are characterized by vicious cycles that generate ROS, which contribute to liver injury

10.1371/journal.pone.0026284 PLoS One

Consequently, BACH1 stabilization leads to the upregulation of key growth factors and their receptors, driving vascular endothelial cell proliferation and tube formation to promote angiogenic repair