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In hooded seal neurons, glutathione synthase (GSS, EC 6.3.2.3), nuclear factor erythroid 2-related Factor 2 (NFE2L2), a transcription factor activating glutathione biosynthesis and the expression of other antioxidants (Cullinan and Diehl, 2004

The convergence of ferroptosis and syn pathology underlines the multifaceted role of dysregulated iron metabolism in exacerbating neurodegeneration in PD

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Subsequently, it was reoxidized and restored back into FAD and NAD + by the mitochondrial respiratory chain

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Reactivity with Amino Acids : Urate hydroperoxide selectively reacted with methionine, cysteine, and glutathione, forming oxidation products like methionine sulfoxide and cystine