glutathione to gsh (GSH) redox cycle in hydroperoxide metabolism. GSSG, Glutathione. (A) Structure of glutathione

GSH synthesis was assessed by measuring -glutamylcysteine ligase (GCL) activity in lung and liver tissue

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Glutathione is present in millimolar concentrations in most mammalian cells and it is involved in several fundamental biological functions, including free radical scavenging, detoxification of xenobiotics and carcinogens, redox reactions, biosynthesis of DNA, proteins and leukotrienes, as well as neurotransmission/neuromodulation

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