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This paper not only reports the first GGDEF I site-type c-di-GMP effector protein, but also identifies the direct target a cell cycle regulator that is targeted for proteolysis thereby revealing that this process is essential for cell cycle progression in

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LBP was the only plasma marker consistently correlated with in vivo permeability measurement in both participants with healthy and higher body weight, showing a variation according to the group studied, from r = 0.423 in those with a healthy body weight up to r = 0.813 in the cohort with obesity [61]

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