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( h ) Cells were treated with succinate and olaparib or cisplatin alone or in combination with or without l-carnitine supplementation (n = 4 technical replicates representative from 2 independent experiments)

Cases of androgen insensitivity can be classified as complete, partial, or mild, and diagnoses are made by observation of female external genitalia in a XY karyotype male fetus (ie., complete androgen insensitivity), gynecomastia and atypical genitalia at puberty (ie., partial androgen insensitivity), or unaffected genitalia yet presence of male infertility (ie., mild androgen insensitivity)

Altogether, these data suggest that sphingolipids participate in the pathophysiology of GDM and highlight the need for further investigation of alterations in placental sphingolipid metabolism

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