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b ) Demographics of all cohorts
Biomed Pharmacother 158:114177

Lancet 355 : 517522
In conclusion, intracellular copper accumulation plays a unique role to kidney fibrosis by activating LOX mediated collagen and elastin crosslinking

However, under conditions of iron overload, excess Fe 2+ in the LIP undergoes Fenton chemistry with H 2 O 2 , producing excessive ROS, promoting lipid peroxidation, and ultimately triggering ferroptosis (Zhao et al., 2025a)

This aqueous solution is blended with a small amount of phenoxyethanol derived from coconut oil (use for preservative properties)
