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International Journal of Molecular Sciences, 2023;24(6), 5344.5 Klubo-Gwiezdzinska J, Wartofsky L
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Endocrine (2003) 20:7582

-LA, a naturally occurring dithiol with antioxidant and anti-inflammatory function, can decrease the interaction between Nrf2 and Keap1, inhibit the pro-inflammatory cytokine IL-8 production and minimize the infection via the Nrf2/HO-1 pathway in the AGS cells (161)

Lesinurad C max was not affected by renal impairment status at either the 200 mg or 400 mg dose
