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Deficient vitamin B12 levels may also lead to damage in the tiny blood vessels in the ear

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The medical terms edema and lymphedema are typically used to refer to this swelling in feet, ankles, and lower legs that is due to fluid retention

The peptide's upregulation of VEGFR2 at both mRNA and protein levels sensitizes healing tissues to angiogenic signals while its activation of the Src-Caveolin-1-eNOS pathway generates nitric oxide essential for vascular development and tissue perfusion

One well-known cause is pernicious anemia

This is why Vitamin B12 therapy can be so helpful: By getting an intramuscular injection of B12, you can bypass the GI tract and allow for up to 100% absorption into the body and straight into your cells