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93,94,95 was used for overlaying the metabolite concentration data to map changes in metabolism at different phases to a global/systems scale

Each study was rated as having low, some concerns, or high risk in various domains, including random sequence generation, allocation concealment, selective reporting, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, and other biases ( 2.5 Statistical analysis The mean change and SD between baseline and last follow-up for TG, TC, HDL, LDL, VLDL, BMI, systolic BP, and diastolic BP in the intervention and control arms were extracted

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