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Cytokine expression is typically induced by the activation of Toll-like receptors (TLRs), which initiate downstream signaling cascades involving NF-B and MAPK pathways [357, 358]

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BMC Genomics (2007) 8:298

For in vivo validation of L2-Cmu blockade, C57BL/6J mice were sedated with 2% isoflurane for surgical placement of an indwelling catheter into the right internal jugular vein 45