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Evidence Evidence that CFS/ME patients are low in methylation cycle metabolites: B vitamin evidence In a small study of 58 chronic fatigue syndrome patients with a history of Epstein-Barr infection and B-cell immunodeficiency, 81% responded to folinic acid

doi: 10.1038/s41587-019-0344-3

PLoS ONE 10(10):e0139956

The deamination of this compound by 3,5-diaminohexanoate dehydrogenase yields the keto acid 3-keto-5-aminohexanoate

Furthermore, chronic inflammatory processes, and specifically the concentration of TNF-, drive cardiovascular events, such as atherosclerosis, atherothrombotic disease, and venous thromboembolism [27]

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