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3 Genetic variants can contribute to gout development through numerous pathways, such as increasing urate production, reducing urate excretion or priming the immune systems inflammatory response to urate crystals

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Signal Transduction Targeted Ther 2022;7:48

The sensitivity and variability of pyruvate dehydrogenase complex activity testing using cultured fibroblasts, WBC lymphocytes, or skeletal muscle tissue for other pyruvate dehydrogenase complex deficiency-associated genes remain to be thoroughly evaluated

Magnolin (MGL) is another lignan produced by plants of the Magnolia genus [491]

This persistent inflammation leads to progressive and irreversible airflow obstruction and the recurrent acute episodes of worsening (exacerbations) that characterise COPD [1, 2]