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Many patients report improved sleep quality and recovery within the first 1-2 weeks

NADPH oxidase NADPH (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that occurs in white blood and vascular cells (Panday et al

Abbreviations ANOVA: Analysis of variance APC: Adenomatous polyposis coli COX-2: Cyclo-oxygenase 2 DCFDA: 2,7-Dichlorofluorescein diacetate DRG: Dorsal root ganglia ELISA: Enzyme-linked immune sorbent assay FBS: Fetal bovine serum GFAP: Glial fibrillary acidic protein GSH: Glutathione GSK3: Glycogen synthase kinase HO-1: Heme oxygenase-1 IHC: Immunohistochemistry IL-6: Interleukin-6 iNOS: Inducible nitric oxide synthase MDA: Malondialdehyde MEM: Minimum essential medium MNCV: Motor nerve conduction velocity MnSOD: Manganese-dependent superoxide dismutase MTT: 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide NGF: Nerve growth factor NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells IB: Inhibitor of B IC50: Inhibitory concentration OIPN: Oxaliplatin-induced peripheral neuropathy PBS: Phosphate-buffered saline ROS: Reactive oxygen species SNCV: Sensory nerve conduction velocity TBARS: Thiobarbituric acid reactive substances TNF-: Tumor necrosis factor T-PER: Tissue protein extraction reagent References de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J et al (2000) Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer

When uncertain, administer separately

[DOI] [PubMed] [Google Scholar] Boridy S

33.Nakano Y., Longo-Guess C.M., Bergstrom D.E., Nauseef W.M., Jones S.M., Bnfi B