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A 2025 study expanded these findings across additional cell lines Cancer incidence: Long-term animal studies reported reduced spontaneous tumor formation in epitalon-treated groups, partially addressing the theoretical concern that telomerase activation could promote malignancy Human observations: Khavinson reported improved clinical outcomes in elderly cohorts receiving epithalamin (the precursor extract) over multi-year observation periods, including reduced cardiovascular mortality, though these were not rigorously controlled trials Evidence Assessment# Epitalon has the broadest evidence base of any bioregulator, with consistent results across decades of study

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