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Additionally, similar to docetaxel, the activation of pro-survival pathways such as the mitogen-activated protein kinase (MAPK) pathway can contribute to resistance by promoting cell survival and proliferation (66)

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These features include: Asymmetry (when a line is drawn down the middle of the mole, the two sides are not the same) Irregular, rather than smooth, round borders Variation in color within the mole, with more than one color Larger than a pencil eraser Patients with numerous (over 50, for instance) benign nevi and/or multiple atypical nevi are at increased risk of melanoma and should be followed by a dermatologist

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