oral glutathione broken down in gut Our Diet and Its Role in the Body: From Disease Prevention to Anti-Aging Effects of Oral Glutathione Supplementation

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ACS Appl Mater Interfaces, 2021, 13: 5361053617 Zhao WB, Chen DD, Liu KK, et al

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(2016) 11:e0156977

With targeting and entering into bioorthogonal molecule azideprelabeled tumor cells, the nanoparticles release EA under the acidic and high GSH environment to inhibit GST activity, while released nitric oxide (NO) from donor GSNO triggered by GSH improves cisplatin uptake, both processes pronouncedly deplete GSH due to simultaneous GSH consumption, collectively reversing cisplatin resistance and inhibiting the growth of cisplatinresistant orthotopic nonsmall cell lung cancer after nebulization