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Nevertheless, its specificity is limited in MASLD due to increased levels also being observed in conditions such as hemochromatosis/HFE mutations, alcohol-related liver disease, and infections

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Naturally, betacarotene is present primarily in all trans configurations in plant sources

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For example, Sb9 A329S variant contributes to the pathogenesis of autoinflammatory disease due to its impaired ability to inhibit caspase-1 and IL-1, indicating Sb9 might play an important role in autoimmune diseases (107), pancreatitis (108), non-alcoholic steatohepatitis (109), severe generalized vitiligo (84), villous atrophy in celiac disease (110), chronic obstructive pulmonary disease (111), infections (69), graft injuries (70, 112), cardiovascular diseases (113), and polycystic ovary syndrome (114)