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The activation of the NLRP3 inflammasome and subsequent release of IL-1 and IL-18 are triggered by innate immune cells like macrophages and dendritic cells, which recognize danger signals and respond by initiating the inflammatory response

50 : 669677 Ellison DW, Beal MF, Martin JB

The gut microbiota as a novel regulator of cardiovascular function and disease

The answer is timing: cell-size variation is an earlier signal than a fall in cell count
