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In addition, that dihydromyricetin-induced ROS downregulation was demonstrated to activate caspase-9 and trigger PARP cleavage, leading to apoptotic cell death in human hepatoma HepG2 cells [50], and that the flavonoid dihydromyricetin reportedly induced apoptosis in Hepal-6 hepatoma cells by reducing ROS generation via the TGF-/Smad3 pathway [51]

Owing to seasonal variations in the occurrence of this disease, it was suggested that a viral cofactor, such as myocarditic strains of the Coxsackie virus, may contribute to disease onset

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The BBB is composed of brain endothelial cells attached to a continuous basement membrane and linked together by tight junctions that prevents foreign substances from entering into the brain 9