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however, dysregulated activation triggers uncontrolled inflammation, leading to tissue damage and organ failure, with copper directly acting as a catalytic metal (Solier et al., 2023)

While its safety profile was consistently favorable, the largest Phase IIb trial failed to show statistical significance for weight loss, and commercial development was halted in 2007.[2] Despite this, interest in AOD-9604 has continued in the compounding pharmacy and integrative medicine space, particularly given its safety data, its lack of IGF-1 stimulation, and emerging research around joint health

In addition, IGF-1 was measured according to a standard protocol under blinded conditions

We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript

Promotion of color-changing luminescent hydrogels from thermo to electrical responsiveness toward biomimetic skin applications