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Description
Wong and Billiar, 1995
We report an additional function for PPP-derived NADPH, as it is also necessary to confine ROS generated during oxidative protein folding in the ER
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A number of pathologic conditions, including IBD, disrupt ER function, resulting in ER stress [98]
[PubMed: 26647380] 89
In humans, age-related NAD+ decline has been observed in the liver, 5 skin, 6 brain, 7,8 plasma, 9 skeletal muscle, 10 and monocyte-derived macrophages
