melanotic macule differential diagnosis Oral pathology: Noting a pigmented that often presents a diagnostic dilemma Differential Diagnosis of Pigmented Lesions

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The encapsulation is often associated with a melanization reaction, which involves prophenoloxidases (PPOs) released into the hemolymph by the crystal cells and activated by a cascade of serine proteases [6], resulting in the deposition of dark melanin, thus hardening the capsule [7]