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Conversely, Western-style diets high in saturated fats and refined sugars drive microbial imbalance, characterized by Bacteroides enrichment and reduced microbial diversity, correlating with chronic inflammation and metabolic syndrome (Mehmood et al., 2021)

de Gruyter

L., Mars W

10.1152/ajpheart.00577.2014 Am J Physiol Heart Circ Physiol

Understanding these mechanistic distinctions, along with their overlapping presentations in many chronic pain states, is paramount for developing accurate diagnosis and targeted interventions

In that setting, CO-related constraints can become more visible and more physiologically costly than they appear under CO alone (Scuffi et al., 2016