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Seek immediate medical help if you develop symptoms of a severe allergic reaction, such as breathing difficulties, confusion, anxiety, clammy skin, and fainting.

Individuals with Raynauds disease experience exaggerated vascular responses to cold that can cause tissue damage and should avoid cold therapy

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Human data is still very limited, including small pilot work such as the knee pain survey of 16 patients, plus a few other early studies and reviews calling out the lack of large, rigorous trials