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Malfunctioning phagocytosis impairs the killing of bacteria that reach the lamina propria through the permeable epithelial barrier, which results in excessive Toll-like receptor stimulation, proinflammatory cytokine secretions, and activation of acquired immune responses, all of which significantly raise intestinal inflammatory reactions in genetically susceptible individuals who harbor mutations in the IBD-susceptibility gene(s) (Duboc et al., 2013)

Other lifestyle interventions, such as moderate exercise, 57 alternating hot and cold showers 58 and a daily meditation practice, 59, 60 also round out a treatment protocol for enhancing energy and boosting perceived quality of life.

Mild digestive discomfort may occur at high doses, but it is generally safe for healthy individuals

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Goodpaster B.H., Sparks L.M