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The overproduction of 5-oxoproline exceeds the capacity of 5-oxoprolinase, and 5-oxoproline therefore accumulates in body fluids and is excreted in the urine

Off-target effects and toxicity to normal tissues remain major challenges for metabolic therapies

doi: 10.1016/j.jcmgh.2023.03.001 46 LvYLiangCSunQZhuJXuHLiXet al

Cu ions can induce toxicity in mice if dosage exceeds levels of 35 mg/kg [26]

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