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The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4

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A key open question is how human and microbial enzymes work together to degrade AGEs and maintain their concentrations within a potentially beneficial range

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Pharmaceutics 18 , 878888 (2021)