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Nat Med 10 , 895896 (2004)
This generates GSSG, often called oxidized GSH, which is reduced by GSH reductase
Compared to the rapid blood elimination of free siG-Cy5 and AsiG-Cy5, the nanosystem greatly prolonged the circulation time of siG-Cy5 in T-AsiG-Cy5-CPL, indicating that CPL can effectively protect and deliver siG to the tumor site during circulation
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