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Long-chain fatty acids (LCFAs) cannot directly cross the mitochondrial membrane because of their high polarity and are activated to long-chain acyl-CoA by acyl-CoA synthetase (ACS)

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LINK Tubbs RS, Loukas M, Shoja MM, Cohen-Gadol AA: Emergency transorbital ventricular puncture: refinement of external landmarks

YuanDKuanTLingHWangHFengLZhaoQet al

Reply Gastroenterology 150 2: 535-7

These modified lysine residues can participate in click chemistry reactions, such as copper-catalyzed azidealkyne cycloaddition (CuAAC) or inverse electron-demand DielsAlder (IEDDA) reactions