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Description
& Avigliano, L

Ferroptosis modulators can be generally classified into three categories: (1) system xc inhibitors, (2) GPX4 inhibitors, and (3) compounds that inhibit GPX4 activity via GSH depletion

255 In contrast, in diabetic nephropathy, HDAC4 represses autophagy in podocytes by deacetylating STAT1 and promoting chromatin compaction at autophagy loci under hyperglycemic conditions, leading to impaired autophagic clearance

Key functions Antioxidant: neutralizes ROS, protecting proteins, lipids, DNA
Retired National Football League (NFL) players, for example, have a threefold increased risk of developing depression after retirement if they had received multiple concussions throughout their career

However, individual responses to anti-VEGF therapy vary significantly, closely related to genetic background
