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Studies have demonstrated that patients with hypogonadism who do not respond to PDE5Is may improve their response to PDE5Is after initiating testosterone therapy [94,374,435]

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Introduction Rett syndrome (RTT, OMIM 312750) is a neurodevelopmental disorder that primarily affects girls and is usually caused by mutation in the X-linked gene Methyl-CpG-binding Protein 2 ( MECP2 ) (Neul et al., 2008)

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