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SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

A KD switches primary energy consumption from glucose to ketones, bypassing the need to utilize the defective complex I and instead primarily utilizing complex II, which may help restore appropriate mitochondrial function and energy production (37)

GRP109a is expressed in macrophages, other immune cells, adipocytes, as well as pancreatic cells (Wang et al., 2016), and activation of the receptor has been shown to have an anti-inflammatory and anti-carcinogenic effect in the intestine (Thangaraju et al., 2009

J.CottinL.DingliF.LaigleV.RibeiroL

Data Availability Statement No new data were created or analyzed in this study

Emerging evidence also indicates that phosphatidylserine may act through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway [16,17,18], which regulates cell survival, metabolism, and inflammatory responses