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In-depth investigation into the tissue-specific functions of these parallel pathways in chondrocytes and their crosstalk with the main GPX4 pathway holds significant translational medical importance for developing novel OA treatment strategies (Figure 1)

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Parks NE, Jackson-Tarlton CS, Vacchi L, Merdad R, Johnston BC

Serious treatment-related adverse events occurred in 20 of 125 patients (16%) in the cabozantinib group and 1 of 62 patients (2%) in the placebo group

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