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CKD-MBD occurs in nearly every patient with stage 5 CKD (eGFR 14 grams) decreased the effectiveness of ACE inhibitor therapy and increased the risk for kidney failure

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Because ceramide-dependent ILV formation is sensitive to the iGSH/nSMase axis, the ATP-driven exporter-mediated loss of iGSH functions as a rapid molecular switch to gate nSMase activity and exosome output

doi: 10.1523/JNEUROSCI.3454-11.2011

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Erratum in: Clin Med Res
