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For example, boron allows vitamin D to be more effective, and vitamin D can increase the effectiveness of resveratrol

Disruption of NADPH production compromises GSH regeneration, limits GPX4-dependent detoxification of lipid peroxides, and can promote ferroptosis even in the absence of impaired GSH synthesis 152

Phytochemistry 116:6977 Cobbett CS, May MJ, Howden R, Rolls B (1998) The glutathione- deficient, cadmium-sensitive mutant, cad2-1, of Arabidopsis thaliana is deficient in gamma-glutamylcysteine synthetase

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Molecular docking, which was based on the CHARMm force field, was applied for each phytochemical compound with the different targeted receptors 33,34 , using vina software packages

The precise mechanism underlying the cardiotoxicity remains elusive, potentially involving oxidative stress, apoptosis, aberrant expression of related genes, calcium overload, and the production of toxic metabolites (McGowan et al., 2017)